Antibiotic apocalypse - is the end nigh?

 

A terrible future could be on the horizon, a future which rips one of the greatest tools of medicine out of the hands of doctors.
A simple cut to your finger could leave you fighting for your life. Luck will play a bigger role in your future than any doctor could.

The most basic operations - getting an appendix removed or a hip replacement - could become deadly.

Cancer treatments and organ transplants could kill you. Childbirth could once again become a deadly moment in a woman's life.

It's a future without antibiotics.

This might read like the plot of science fiction novel - but there is genuine fear that the world is heading into a post-antibiotic era.

The World Health Organization has warned that "many common infections will no longer have a cure and, once again, could kill unabated".

The US Centers of Disease Control has pointed to the emergence of "nightmare bacteria".

Antibiotics kill bacteria, but the bugs are incredibly wily foes. Once you start treating them with a new drug, they find ways of surviving. New drugs are needed, which they then find ways to survive.

Deadly

As long as new drugs keep coming, resistance is not a problem. But there has not been a new class of antibiotics discovered since the 1980s.

This is now a war, and one we are in severe danger of losing.

Antibiotics are more widely used than you might think and a world without antibiotics would be far more dangerous.

They made deadly infections such as tuberculosis treatable, but their role in healthcare is far wider than that.

Surgery that involves cutting open the body posses massive risks of infection. Courses of antibiotics before and after surgery have enabled doctors to perform operations that would have been deadly before.

Cancer treatments such as chemotherapy and radiotherapy can damage the immune system. A course of antibiotics is prescribed to provide a much-needed boost alongside your body's own defences.

Anyone with an organ transplant faces a lifetime of drugs to suppress the immune system, otherwise it attacks the transplant, so antibiotics are used to protect the body.

"It's a pretty grim future, I think a lot of major surgery would be seriously threatened," said Prof Richard James from the University of Nottingham.

"I used to show students pictures of people being treated for tuberculosis in London - it was just a row of beds outside a hospital, you lived or you died - the only treatment was fresh air."

And this, he says, is what running out of drugs for tuberculosis would look like in the future.

But this is all in the future isn't it?

"My lab is seeing an increasing number of resistant strains year on year," said Prof Neil Woodford, from the Health Protection Agency's antimicrobial resistance unit.

Down to luck

He said most cases were resistant to some drugs, known as multi-drug resistant strains, but there were a few cases of pan-drug resistant strains which no antibiotic can touch.

Prof Woodford said the worst case scenario would "be like the world in the 1920s and 30s".

"You could be gardening and prick your finger on a rose bush, get a bacterial infection and go into hospital and doctors can't do anything to save your life. You live or die based on chance.

"But for many infections that wouldn't happen."

Opportunistic infections - those that often hit the elderly when they are already ill and vulnerable in hospital - are one of the main concerns.

Prof Woodford says the greatest threat in the UK is Enterobacteriaceae - opportunistic bugs that live in the gut such as E. coli and Klebsiella.

They are now the most common form of hospital acquired infection and they show rising levels of resistance.

The number of tests coming back with resistance to carbapenems, one of the most powerful groups of antibiotics, has soared from a handful of cases in 2003 to more than 300 cases by 2010.

It has also raised concerns about the sexually transmitted disease gonorrhoea which is becoming increasingly difficult to treat.

Around the world, multi-drug resistant and extremely-drug resistant tuberculosis - meaning only a couple of drugs still work - is a growing problem.

Global problem

Relatively speaking the UK is doing well.

"A world without antibiotics has happened in some countries," says Prof Timothy Walsh, from Cardiff University.

He was part of the team that identified one of the new emerging threats in south Asia - NDM-1.

This gene gives resistance to carbapenems and has been found in E. coli and Klebsiella.

"Antibiotic resistance in some parts of the world is like a slow tsunami, we've known it's coming for years and we're going to get wet," he said.

New Dehli Metallo-beta-lactamase-1 (NDM-1) is thought to have emerged in India where poor sanitation and antibiotic use have helped resistance spread.

But due to international travel, cases have been detected around the world including in the UK.

This highlights one of the great problems with attempting to prevent an antibiotic catastrophe - how much can one country do?

There are wide differences in how readily antibiotics are used around the world. They are prescription-only drugs in some countries and available over the counter in others.
Economic impact

There are still question about doctors giving antibiotics to patients with viral infections like the common cold - antibiotics do nothing against viruses.

Europe has banned the use of antibiotics to boost the growth of livestock as it can contribute to resistance.

But the practice is common in many parts of the world and there is a similar issue with fish farms.

Prof Laura Piddock, from Birmingham University and the group Antibiotic Action, said: "These are valuable drugs and we need to use them carefully."

Some people have even suggested that antibiotics need to be far more expensive - something more like the price of new cancer drugs - in order for them to be used appropriately.

The doomsday scenario is on the horizon, but that does not mean it will come to pass.

A renewed focus on developing new antibiotics and using the ones that still work effectively would change the picture dramatically.

But if it does happen, the impact on society will be significant.

Prof Piddock said: "Every time we can't treat an infection, a patient spends longer in hospital and there is the economic impact of not being in education or work.

"The consequences are absolutely massive, that's actually something people have not quite grasped."

New DNA science may lead to better treatment for acne

New DNA science may lead to better treatment for acne. Infomercials promise to cure it, cosmetics try to conceal it, drugstore tinctures claim to clear it, home remedies aim to tame it — all to little effect. Acne, which pesters 85 percent of Americans at some point, has proven to be wildly stubborn and difficult to understand.

Dermatologists generally agree that acne occurs when the skin’s bacteria, including Propionibacterium acnes, feeds on oils in the pores and incites an immune response, leading to blemishes.

But in a new study that employed state-of-the-art DNA sequencing techniques to examine the bacteria in the skin of 101 study volunteers, researchers discovered something surprising. They found variations in P. acnes, and that a “good” strain of the bacteria seemed to be fighting other versions that are more potent acne instigators. The study participants who had the good bacterial strain didn’t have acne, according to the report published Feb. 28 in the Journal of Investigative Dermatology.

The team then sequenced the complete genomes of the specimens to explore in depth how the good and bad strains were different.

The discovery that "not all P. acnes are created equal" might help dermatologists devise treatments that more precisely target bad strains while allowing beneficial ones to thrive, said Dr. Noah Craft, a dermatologist at the Los Angeles Biomedical Research Institute who worked on the study with colleagues from UCLA and Washington University in St. Louis.

The development of probiotic creams that deliver "good" P. acnes to the skin could work in a way similar to the way eating yogurt with beneficial bacteria can restore the balance in the gut.

"There are healthy strains that we need on our skin," Craft said. "The idea that you'd use a nuclear bomb to kill everything — what we're currently doing with antibiotics and other treatments — just doesn't make sense."

The research is just one part of a comprehensive endeavor supported by the National Institutes of Health to map the human microbiome; the trillions of microbes that live in and on our bodies, described as “the ecological community of symbiotic, and pathogenic microorganisms that literally share our body space.”

Study leader Huiying Li, assistant professor of molecular and medical pharmacology at UCLA's Geffen School of Medicine, said the researchers were unable to determine why some people had the good bacterial strains and some did not, and whether genetics or environment played a bigger role.

More research will be necessary to develop precise anti-microbial therapies or to come up with a probiotic cream for acne sufferers. But Li and Craft plan to keep up the work, to the relief of teenagers everywhere.